Which of the following is a side effect of spironolactone?

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Multiple Choice

Which of the following is a side effect of spironolactone?

Explanation:
Spironolactone acts as an aldosterone antagonist and also has antiandrogenic effects. Those antiandrogenic properties explain why gynecomastia is a classic and well-recognized side effect in men, due to reduced androgen activity in breast tissue. The drug saves potassium in the distal tubule, so it tends to cause hyperkalemia rather than hypokalemia, making low potassium an unlikely side effect. Dyspepsia and photosensitivity can occur with various meds but are not defining or as strongly linked to spironolactone as gynecomastia is. Therefore gynecomastia is the best answer.

Spironolactone acts as an aldosterone antagonist and also has antiandrogenic effects. Those antiandrogenic properties explain why gynecomastia is a classic and well-recognized side effect in men, due to reduced androgen activity in breast tissue. The drug saves potassium in the distal tubule, so it tends to cause hyperkalemia rather than hypokalemia, making low potassium an unlikely side effect. Dyspepsia and photosensitivity can occur with various meds but are not defining or as strongly linked to spironolactone as gynecomastia is. Therefore gynecomastia is the best answer.

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