Thiazolidinediones are contraindicated in which condition?

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Multiple Choice

Thiazolidinediones are contraindicated in which condition?

Explanation:
Thiazolidinediones can cause fluid retention and edema by promoting sodium and water reabsorption in the kidneys. This fluid buildup can precipitate or worsen heart failure, making these agents contraindicated in patients with congestive heart failure, especially if it is symptomatic. Because of this risk, they should be avoided in individuals with active or decompensated heart failure. Liver concerns have historically been associated with troglitazone, another drug in this class, but that doesn’t apply to all thiazolidinediones in the same way. Hypertension and asthma aren’t specific contraindications for this class.

Thiazolidinediones can cause fluid retention and edema by promoting sodium and water reabsorption in the kidneys. This fluid buildup can precipitate or worsen heart failure, making these agents contraindicated in patients with congestive heart failure, especially if it is symptomatic. Because of this risk, they should be avoided in individuals with active or decompensated heart failure.

Liver concerns have historically been associated with troglitazone, another drug in this class, but that doesn’t apply to all thiazolidinediones in the same way. Hypertension and asthma aren’t specific contraindications for this class.

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