Paget's disease of the breast most commonly involves which tissue?

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Multiple Choice

Paget's disease of the breast most commonly involves which tissue?

Explanation:
Paget's disease of the breast presents with eczematous, crusted changes of the nipple-areola, reflecting involvement of the skin in that area. Malignant Paget cells infiltrate the epidermis of the nipple-areolar skin, often arising from ducts but extending to the surface so that the skin of the nipple and areola is the tissue most commonly involved. While there is frequently an underlying ductal carcinoma, the primary tissue affected in this disease process is the nipple-areolar skin, not the deeper glandular tissue, subcutaneous chest wall, or ductal epithelium alone.

Paget's disease of the breast presents with eczematous, crusted changes of the nipple-areola, reflecting involvement of the skin in that area. Malignant Paget cells infiltrate the epidermis of the nipple-areolar skin, often arising from ducts but extending to the surface so that the skin of the nipple and areola is the tissue most commonly involved. While there is frequently an underlying ductal carcinoma, the primary tissue affected in this disease process is the nipple-areolar skin, not the deeper glandular tissue, subcutaneous chest wall, or ductal epithelium alone.

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