Janeway lesions and Osler's nodes are signs of what condition?

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Multiple Choice

Janeway lesions and Osler's nodes are signs of what condition?

Explanation:
Janeway lesions and Osler's nodes are classic signs of infective endocarditis. Janeway lesions are painless, hemorrhagic spots on the palms or soles caused by septic emboli from infected heart valves. Osler nodes are tender, subcutaneous nodules on the fingers or toes that arise from immune complex deposition in the skin. Together, they reflect the vascular and immune processes that occur with endocarditis, where valve infection can send emboli and provoke immune reactions. The other conditions listed—eczema, lupus, and psoriasis—have skin findings that arise from different pathophysiologic processes and are not associated with these endocarditis-related signs.

Janeway lesions and Osler's nodes are classic signs of infective endocarditis. Janeway lesions are painless, hemorrhagic spots on the palms or soles caused by septic emboli from infected heart valves. Osler nodes are tender, subcutaneous nodules on the fingers or toes that arise from immune complex deposition in the skin. Together, they reflect the vascular and immune processes that occur with endocarditis, where valve infection can send emboli and provoke immune reactions. The other conditions listed—eczema, lupus, and psoriasis—have skin findings that arise from different pathophysiologic processes and are not associated with these endocarditis-related signs.

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