In women, infection with HPV is associated with development of which cancer?

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Multiple Choice

In women, infection with HPV is associated with development of which cancer?

Explanation:
HPV infection, especially high-risk types such as 16 and 18, is the primary driver of cervical cancer in women. The virus can infect cervical epithelial cells and integrate its DNA into the host genome, producing E6 and E7 oncoproteins that disable the tumor suppressors p53 and Rb. This disrupts normal cell cycle control, allowing progression from precancerous lesions to invasive cancer. HPV is sexually transmitted, which is why vaccination and regular screening with Pap tests and HPV testing help catch precancerous changes early. While HPV can be involved in some other cancers (such as certain vulvar or oropharyngeal cancers), the classic and most strongly linked cancer in women is cervical cancer.

HPV infection, especially high-risk types such as 16 and 18, is the primary driver of cervical cancer in women. The virus can infect cervical epithelial cells and integrate its DNA into the host genome, producing E6 and E7 oncoproteins that disable the tumor suppressors p53 and Rb. This disrupts normal cell cycle control, allowing progression from precancerous lesions to invasive cancer. HPV is sexually transmitted, which is why vaccination and regular screening with Pap tests and HPV testing help catch precancerous changes early. While HPV can be involved in some other cancers (such as certain vulvar or oropharyngeal cancers), the classic and most strongly linked cancer in women is cervical cancer.

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