Fitz-Hugh-Curtis syndrome is a complication of pelvic inflammatory disease most commonly associated with infection by which organism?

• A. Neisseria gonorrhoeae
• B. Chlamydia trachomatis
• C. Treponema pallidum
• D. Gardnerella vaginalis

Answer: (B)

Fitz-Hugh-Curtis syndrome is perihepatitis that can occur as a complication of pelvic inflammatory disease. The organism most commonly associated with this condition is Chlamydia trachomatis, because chlamydial infections are a leading cause of PID and often present with subacute symptoms that allow the infection to ascend and involve the liver capsule, producing right upper quadrant pain and the characteristic peritoneal involvement around the liver. While Neisseria gonorrhoeae can also cause PID, Chlamydia trachomatis remains the most frequent association in this syndrome. Treponema pallidum (syphilis) and Gardnerella vaginalis (bacterial vaginosis) are not typical causes of Fitz-Hugh-Curtis.